Tretinoin

18+ · Prescription-only — consult your prescriber. We hold no product. Disclaimer.

The original prescription retinoid — acne, texture, pigmentation and photoaging. Sold in the US as Retin-A. It accelerates cell turnover, which is also why it irritates before it improves.

What it actually costs · 0.025%

5.2× — and it holds up against a free coupon

Route Price Per gram
US retail45g tube $278.25 $6.183
US, free GoodRx couponno account, no membership $57.33 $1.274
US, GoodRx Companionpaid, $9.99–$14.99/mo $26.43 $0.587
Overseas, GMP-verifiedMenarini India · 20g · 6-tube tier $4.91 $0.245

Checked 15 Aug 2026 · ZIP 37996 · varies by pharmacy — check yours

We quote the multiple for the product we actually recommend. A second gel works out to $0.185/g, which would let us print 6.9× — but its manufacturer is unidentified, so it is rated Partial. Against the named GMP maker the figure is 5.2×. Both are in the source sheet; the choice is yours, stated openly.

Note the Companion row: a paid membership brings the US to $0.587/g, narrowing the gap to about 2.4×. If you already pay for Companion, factor that in.

Verified sources

  • 🔒 ████████ — ✅ Menarini India · 0.025 / 0.05 / 0.1% · both pharmacies
  • 🔒 ████████ — ⚠️ Partial · cheapest per gram, manufacturer unidentified

🔓 Unlock verified sources — $9 →

Start at the lowest strength. Retinoid irritation in the first weeks is normal and not a reason to escalate.